Anti Cancer Drugs Essay Example | Topics and Well Written Essays - 500 words

Anti Cancer Drugs - Essay Example Cell cycle phase specific anticancer drugs are given for a particular phase and inhibit the further progression of the tumor cell (Ajithkumar et al 2011). The G1 phase specific drugs inhibit the G1 phase of the tumor cells and have therapeutic consequences associated with them. Cyclin-dependant kinases play an important role in the progression of the G1 phase. During the G1 to S phase transition, the phosphorylation of retinoblastoma susceptibility gene, Rb, regulated by D-type cyclins and CDKs 4 and 6 is a major factor causing the cell cycle progression. By inhibiting the CDK activity, the G1 phase activity can be inhibited as well. First generation CDK inhibitors include flavopiridol, UCN-01 and L86 8276, a non-chlorinated chemical form of flavopiridol. Flavopiridol causes G1 inhibition by its inhibitory action on the CDK 2 and CDK4. UCN-01 and flavopiridol cell cycle repression is followed by apoptosis of the tumor cells and they cave a cytotoxic effect. However, tumor cell selectivity is a major issue in their therapeutic affectivity. Non-tumor cells can also be affected by these anticancer drugs leading to apoptosis and hence, non-tumor cells are also sensitive for the CDK inhibiting action (Shapiro & Harper 1999). The limited inhibition activity caused by first-generation lead to the formulation of purvalanol B a second generation CDK inhibitor. This drug targets the ATP-binding sites and has shown higher selectivity for the CDKs. The activity of CDK4 and CDK 2 is inhibited 100-folds more selectively causing inactivation of Rb gene and ultimately cell arrest at the G1 phase (Shapiro & Harper 1999). Corticosteroids and natural products like asparagine are also specific for cell arrest at G1 phase of the tumor cells. Corticosteroids are effective in lymphoid derived tumors while asparagines are effective in depriving the tumor cells

Reflective Account Essay Example | Topics and Well Written Essays - 2500 words - 1

Reflective Account - Essay Example 3. Generalised analysis and learning - moving away from the specific example, what did this raise about how the volunteering practice and theory relate to each other more generally (e.g. did a conversation raise any issues about the methods used by the agency? or about working professionally? or did the meeting or activity raise issues about policy or systems or procedures?) The conversation really made me understand the importance of volunteering practice as a bridge between theoretical work and practice. The school encourages teachers to be very close to the unique needs of students. The teachers are expected to act on the student’s needs in manners that motivate and encourage renewed energy. This was one case invoked me to place myself as the teacher in the shoes of the student in Oder to understand her predicament and act practically appropriately. Following the conversation I saw the need to follow up and assist motivate the student so as to help her develop a better self image despite the situation. My follow up will involve helping the girl adopt strategies that help her turn her situation into an opportunity to excel in her academic and general life. In future as part of my learning and development I will be more careful hewn handling learners from different social, cultural and economic backgrounds. These are factors affecting behaviour and communication among learners and as a teacher I need to be more proactive and culturally